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17-AAG 
17-​demethoxy-​17-​(2-​propenylamino)-​geldanamycin
(CAS 75747-14-7)
Description:

Geldanamycin (Item No. 13355) is a potent inhibitor of Hsp90 that exhibits severe hepatotoxicity when used in vivo.1 17-AAG is an analog of geldanamycin which has potent in vivo activity and reduced toxicity.1,2,3 Like other Hsp90 inhibitors, 17-AAG has diverse anti-tumor actions and has potential in treating certain types of cancer.1,2,3 17-AAG inhibits the growth of prostate cancer cell lines (IC50 = 25-45 nM).4 17-AAG promotes the degradation of HER2 and induces growth arrest and apoptosis in breast cancer cells overexpressing HER2 (IC50 = 4-72 nM).5

 

Product No. KT00009 
Product Name 17-AAG 
Synonyms BMS 722782,CP 127374,NSC 330507,Tanespimycin,KOS 953
Formal Name 17-​demethoxy-​17-​(2-​propenylamino)-​geldanamycin
CAS Number 75747-14-7
Molecular Formula C31H43N3O8
Formula Weight 585.7
Formulation A solution in methanol
Purity 98%min
Stability 1 year
Storage -20℃
Shipping USD45 for Europe and USA. No shipping charge once amount reach USD500.
Quality Control HNMR,CNMR,LCMS,HPLC,IR,etc.
Price & Availability In Stock. Price Negotiated.
 
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