Tel:+86-21-51950625 51950635
Email us at sales@koutingchina.com
   
Products
Brivanib alaninate 
(S)-((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[1,2-f][1,2,4]triazin-6-yloxy)propan-2-yl) 2-aminopropanoate
(CAS 649735-63-7)
Description:

Brivanib alaninate(BMS582664) is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold against PDGFR-β.
IC50 value: 25 nM
Target: VEGFR2
in vitro: Brivanib also inhibits VEGFR1 and FGFR-1 with IC50 of 0.38 μM and 0.148 μM. Brivanib is not sensitive to PDGFRβ, EGFR, LCK, PKCα or JAK-3 with IC50 all above 1900 nM. Brivanib could inhibit the proliferation of VEGF-stimulated HUVECs with IC50 of 40 nM, compared to 276 nM in FGF-stimulated HUVECs. On the other hand, Brivanib exhibits low activity to tumor cell lines [1].
in vivo: Brivanib displays antitumor activities in H3396 xenograft in athymic mice. At a dose of 60 and 90 mg/kg (p.o.), Brivanib completely inhibits the tumor growth, with TGI of 85% and 97%, respectively [1]. Moreover, Brivanib significantly suppresses tumor growth in Hepatocellular carcinoma (HCC) xenografts, which due to the decrease in phosphorylation of VEGFR2. The results show that the tumor weights in 06-0606 xenograft mice are 55% and 13%, compared with the controls at a dose of 50 mg/kg and 100 mg/kg. Brivanib is suggested to be efficient in treatment of HCC [2].

 

Product No. KT20013 
Product Name Brivanib alaninate 
Synonyms BMS-582664; BMS 582664; BMS582664
Formal Name (S)-((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[1,2-f][1,2,4]triazin-6-yloxy)propan-2-yl) 2-aminopropanoate
CAS Number 649735-63-7
Molecular Formula C22H24FN5O4
Formula Weight 441.46
Formulation A crystalline solid
Purity 98%min
Stability 1 year
Storage -20°C
Shipping USD45 for Europe and USA. No shipping charge once amount reach USD500.
Quality Control HNMR,CNMR,LCMS,HPLC,IR,etc.
Price & Availability In Stock. Price Negotiated.
 
Not found? Pls contact with us for sourcing service.
Our contact email:sales@koutingchina.com
 
 
 
 
Related Products:

Apatinib
Axitinib
AZD2932
BIBF 1120
BMS-690514
Bosutinib
Erlotinib
Mubritinib
Pelitinb

Order the product  * is required
Product:*
Your Name:*
Your Company:*
Add:
Tel:
Fax:
Web:
E-Mail:*
Your Demand :*
Products are for research use only. Not for human use. We do not sell to patients.
Copyrigh ©2009,China Kouting Group Limited All Rights Reserved. Supported by hxchem.net


products
Customer Service
Why Choose Us?
How to Order
How to Ship
How to Return
Frequently Asked Questions
Terms and Conditions
Email:sales@koutingchina.com
Skype: