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Sorafenib Tosylate 
1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)urea mono(4-methylbenzenesulfonate)
(CAS 4750207-59-1)
Description:

Sorafenib (co-developed and co-marketed by Bayer and Onyx Pharmaceuticals as Nexavar),[1] is a drug approved for the treatment of primary kidney cancer (advanced renal cell carcinoma) and advanced primary liver cancer (hepatocellular carcinoma). Sorafenib (a bi-aryl urea[2]) is a small molecular inhibitor of several Tyrosine protein kinases (VEGFR and PDGFR) and Raf kinases (more avidly C-Raf than B-Raf). (Protein kinases are overactive in many of the molecular pathways that cause cells to become cancerous. These pathways include Raf kinase, PDGF (platelet-derived growth factor), VEGF receptor 2 and 3 kinases and c Kit the receptor for Stem cell factor. ) Sorafenib is/was unique in targeting the Raf/Mek/Erk pathway (MAP Kinase pathway). Sorafenib inhibits some intracellular serine/threonine kinases (e.g. C-Raf, wild-type B-Raf and mutant B-Raf).

 

Product No. KT20011 
Product Name Sorafenib Tosylate 
Synonyms BAY 43-9006;Nexavar(R);UNII-5T62Q3B36J
Formal Name 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)urea mono(4-methylbenzenesulfonate)
CAS Number 4750207-59-1
Molecular Formula C21H16ClF3N4O3
Formula Weight 637.03
Formulation A crystalline solid
Purity 98%min
Stability 1 year
Storage -20℃
Shipping USD45 for Europe and USA. No shipping charge once amount reach USD500.
Quality Control HNMR,CNMR,LCMS,HPLC,IR,etc.
Price & Availability In Stock. Price Negotiated.
 
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