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Gefitinib 
N-​(3-​chloro-​4-​fluorophenyl)-​7-​methoxy-​6-​[3-​(4-​morpholinyl)propoxy]-​4-​quinazolinamine
(CAS 184475-35-2)
Description:

Overactivity of the epidermal growth factor receptor-associated tyrosine kinase (EGFR-TK) has been associated with a number of cancers and thus TK inhibitors could be potential therapeutic agents to prevent malignant growth. Gefitinib is a selective EGFR-TK inhibitor that blocks the growth of GEO colon cancer, ZR-75-1 and MCF-10A Ha-ras breast cancer, and OVCAR-3 ovarian cancer cell lines with IC50s ranging between 0.2-0.4 µM. By interfering with the intracellular kinase domain, gefitinib prevents EGFR autophosphorylation and prevents downstream signal transduction. Gefitinib has been used to treat advanced (or recurrent) non-small cell lung cancer. However, the FDA retracted its general approval for this compound (Iressa™) when a phase III trial failed to demonstrate an overall survival benefit. Gefitinib appears to be most efficacious in treating certain EGFR gene mutations that are prevalent in Asian populations.

 

Product No. KT20006 
Product Name Gefitinib 
Synonyms Iressa; ZD 1839; ZD-1839; ZD1839
Formal Name N-​(3-​chloro-​4-​fluorophenyl)-​7-​methoxy-​6-​[3-​(4-​morpholinyl)propoxy]-​4-​quinazolinamine
CAS Number 184475-35-2
Molecular Formula C22H24ClFN4O3
Formula Weight 446.9
Formulation A crystalline solid
Purity 98%min
Stability 1 year
Storage -20°C
Shipping USD45 for Europe and USA. No shipping charge once amount reach USD500.
Quality Control HNMR,CNMR,LCMS,HPLC,IR,etc.
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