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ABT-888 
2-​[(2R)-​2-​methyl-​2-​pyrrolidinyl]-​1H-​benzimidazole-​7-​carboxamide,​ dihydrochloride
(CAS 912445-05-7)
Description:

Poly(ADP-ribose) polymerases (PARPs) have diverse roles in cellular processes, including DNA repair and apoptosis. ABT-888 is an orally bioavailable inhibitor of PARP1 and PARP2 (Kis = 5.2 and 2.9 nM, respectively). It enhances apoptosis and autophagy in response to treatments that cause DNA breaks, including radiation and DNA alkylation. ABT-888 is an orally bioavailable inhibitor of PARP1 and PARP2 (Kis = 5.2 and 2.9 nM, respectively). It enhances apoptosis and autophagy in response to treatments that cause DNA breaks, including radiation and DNA alkylation. ABT-888 also acts synergistically with chemotherapies to increase the lethal effects of radiation in cancer cells.

 

Product No. KT00030 
Product Name ABT-888 
Synonyms Veliparib
Formal Name 2-​[(2R)-​2-​methyl-​2-​pyrrolidinyl]-​1H-​benzimidazole-​7-​carboxamide,​ dihydrochloride
CAS Number 912445-05-7
Molecular Formula C13H16N4O • 2HCl
Formula Weight 317.2
Formulation A crystalline solid
Purity 98%min
Stability 1 year
Storage -20°C
Shipping USD45 for Europe and USA. No shipping charge once amount reach USD500.
Quality Control HNMR,CNMR,LCMS,HPLC,IR,etc.
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