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ABT263 
4-​[4-​[[2-​(4-​chlorophenyl)-​5,​5-​dimethyl-​1-​cyclohexen-​1-​yl]methyl]-​1-​piperazinyl]-​N-​[[4-​[[(1R)-​3-​(4-​morpholinyl)-​1-​benzamide
(CAS 923564-51-6)
Description:

The family of Bcl-2 proteins plays pivotal roles in either promoting or preventing apoptosis. Bcl-2 family members contain one or more of four characteristic Bcl-2 homology (BH) domains, which are crucial for function. For example, anti-apoptotic Bcl-2 family proteins prevent death signaling by heterodimerizing with pro-death proteins at their BH3 domains. ABT-263 is a potent, orally bioavailable mimetic of BH3 domains that avidly binds Bcl-2, Bcl-XL, and Bcl-W (Ki < 1 nM for all three proteins). It blocks the interaction of these proteins with pro-death proteins, like Bim, leading to apoptosis. ABT-263, alone, can induce regression of some tumors in some xenograft mouse models of cancer. It can also potentiate the therapeutic efficacy of chemotherapeutic compounds. Interestingly, ABT-263 induces apoptosis in cancer cell lines expressing mutants of β-catenin a Wnt signaling factor commonly mutated in a range of cancer types.

 

Product No. KT00025 
Product Name ABT263 
Synonyms A-855071
Formal Name 4-​[4-​[[2-​(4-​chlorophenyl)-​5,​5-​dimethyl-​1-​cyclohexen-​1-​yl]methyl]-​1-​piperazinyl]-​N-​[[4-​[[(1R)-​3-​(4-​morpholinyl)-​1-​benzamide
CAS Number 923564-51-6
Molecular Formula C47H55ClF3N5O6S3
Formula Weight 974.6
Formulation A crystalline solid
Purity 98%min
Stability 1 year
Storage -20℃
Shipping USD45 for Europe and USA. No shipping charge once amount reach USD500.
Quality Control HNMR,CNMR,LCMS,HPLC,IR,etc.
Price & Availability In Stock. Price Negotiated.
 
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