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A-803467 
5-​(4-​chlorophenyl)-​N-​(3,​5-​dimethoxyphenyl)-​2-​furancarboxamide
(CAS 944261-79-4)
Description:

Nav1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel with high activation threshold and slow inactivating kinetics that is highly expressed in small-diameter sensory neurons and has been implicated in signaling various types of pain. A-803467 is a sodium channel blocker with high-affinity and selectivity for inhibiting human Nav1.8 sodium channels (IC50 = 8 nM when stimulated at half-maximal inactivation and IC50 = 79 nM at a resting state).  This compound is unusual in that it blocks hNav1.8 at negative resting membrane potentials (many small molecule sodium channel blockers show a reduced affinity for the resting state) and does not demonstrate significant frequency-dependent block during a 10 Hz pulse train. A-803467 dose-dependently reduces behavioral responses in a variety of neuropathic and inflammatory pain models.

 

Product No. KT00017 
Product Name A-803467 
Synonyms
Formal Name 5-​(4-​chlorophenyl)-​N-​(3,​5-​dimethoxyphenyl)-​2-​furancarboxamide
CAS Number 944261-79-4
Molecular Formula C19H16ClNO4
Formula Weight 357.8
Formulation A crystalline solid
Purity 98%min
Stability 1 year
Storage -20℃
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