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A-769662 
6,​7-​dihydro-​4-​hydroxy-​3-​(2’-​hydroxy[1,​1’-​biphenyl]-​4-​yl)-​6-​oxo-​thieno[2,​3-​b]pyridine-​5-​carbonitrile
(CAS 844499-71-4)
Description:

AMP-activated protein kinase (AMPK) is an αβγ heterotrimer that functions as a metabolic sensor, regulating lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress. A-769662 is a small molecule thienopyridone that activates AMPK directly in cell-free assays (EC50 = 116 nM) and intact cells by allosterically activating AMPK and inhibiting its dephosphorylation on Thr172.A-769662 specifically activates β1 subunit-containing AMPK heterotrimers, and its effects are independent of kinases upstream of AMPK. A-769662 has been used to stimulate CYP450-mediated fatty acid oxidation, inhibit adipocyte differentiation, explore glucose uptake in skeletal muscle, and promote endothelial cell survival during metabolic stress.

 

Product No. KT00015 
Product Name A-769662 
Synonyms
Formal Name 6,​7-​dihydro-​4-​hydroxy-​3-​(2’-​hydroxy[1,​1’-​biphenyl]-​4-​yl)-​6-​oxo-​thieno[2,​3-​b]pyridine-​5-​carbonitrile
CAS Number 844499-71-4
Molecular Formula C20H12N2O3S
Formula Weight 360.4
Formulation A crystalline solid
Purity 98%min
Stability 1 year
Storage -20℃
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Quality Control HNMR,CNMR,LCMS,HPLC,IR,etc.
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